Juventus dominated throughout but were held to a 1-1 draw at home to Nantes after Ludovic Blas scored a priceless equaliser in the Europa League play-off.
Massimiliano Allegri's side fell into this competition after a dire Champions League campaign, finishing third in Group H, but looked good value for their early first-leg lead on Thursday.
Dusan Vlahovic tapped home after 13 minutes at Allianz Stadium, only for Blas to finish a flowing counter-attack in the second half before Juve were left aggrieved after a late VAR check deemed Andrei Girotto had not handled for a penalty in the dying minutes.
That left it all to play for in the return meeting at Beaujoire Stadium on February 23 after a wasteful Juve offered Nantes the chance for a memorable European night at home.
Angel Di Maria stung the palms of Alban Lafont with an early drive and Nantes did not heed the opening warning signs from Argentina's World Cup winner.
A delicate Di Maria chipped pass found Federico Chiesa to selflessly nod across for Vlahovic to convert from point-blank range.
Lafont parried another ferocious Di Maria long-range effort as a tepid Nantes were fortunate to head in at half-time just a goal down.
A clinical counter-attack drew Nantes level on the hour as Blas capitalised on Bremer's slip to race onto Mostafa Mohamed's pass and fire past Wojciech Szczesny.
Chiesa rattled the crossbar and Lafont's left post with a venomous left-footed strike that somehow bounced off the line and away from goal as Juve looked to respond.
Danilo blazed over on the volley before Girotto was deemed not to have handled when challenging a late Bremer headed chance, with the referee awarding a free-kick for a push on Girotto instead, leaving it all to play for in France next week.