Nicolo Barella and Romelu Lukaku scored as Inter earned a 2-0 victory at Benfica in their Champions League quarter-final first leg on Tuesday.
In a tense affair at the Estadio da Luz, both teams found it hard to create opportunities, though the hosts shaded the first half as they pressed to get their noses in front on home soil.
But a rare moment of attacking quality from Barella put Inter ahead, before substitute Lukaku scored from the spot to clinch the win for the Serie A side.
Simone Inzaghi's men are now very much in control heading into the second leg, set to be played at San Siro next Wednesday.
The first half was a cagey affair with clear-cut chances few and far between, though Rafa Silva nearly punished a mistake when he saw a blasted effort denied by Andre Onana after pouncing upon Federico Dimarco's loose header.
Francesco Acerbi also sent a fierce drive from range just over the crossbar as the game went into the interval goalless, with Inter managing just two touches in Benfica's box in the first half.
But the visitors would take the lead in the 51st minute with their first shot on target, Barella's delightful back-post header nestling in the bottom corner after Alessandro Bastoni's cross picked him out.
The hosts nearly levelled when Rafa saw a shot blocked before an almighty goalmouth scramble ended with Inter finally clearing.
Henrikh Mkhitaryan could, and perhaps should, have doubled his side's advantage after he was played in by Joaquin Correa, but his shot from a tight angle was well saved by Odisseas Vlachodimos.
Inter would add a second goal before the end, though, as Lukaku lashed home a penalty after Joao Mario handled Denzel Dumfries' cross to leave the Portuguese side up against it if they are to reach the semi-finals.
What does it mean? Inter in the ascendancy after great away showing
Inzaghi's men had not won in six prior to this, and they looked very much the out-of-form team in the opening 45 minutes as Benfica held them to just two shots, neither of which hit the target.
But the Serie A side came out firing in the second half, creating five big chances and taking two of them to put themselves in the driver's seat as they bid to win this competition for a fourth time.
Lukaku continues fine form
Lukaku has not enjoyed one of the best seasons of his career, but he came on to great effect here to score what could be a vital second goal and make it six in his last six matches in all competitions for club and country.
Vlachodimos guessed the right way for his penalty, but the power on it meant it flew past him anyway, and the Belgium international has now scored 16 times in his last 17 appearances in major European competitions for Inter, including nine in his last 11 Champions League games for the Italian side.