Connect with us

News

New HIV Vaccine With A 97% Antibody Response Rate Shows Promise In ‘Landmark’ First-In-Human Trial

Published

on

A novel vaccine approach for the prevention of HIV has shown promise in Phase I trials.

IAVI and Scripps Research reported that the vaccine which is being developed to act as an immune primer, to trigger the activation of naïve B cells via a process called germline-targeting, as the first stage in a multi-step vaccine regimen to elicit the production of many different types of broadly neutralizing antibodies (bnAbs), successfully stimulated the production of the rare immune cells needed to generate antibodies against HIV in 97 percent of participants.

European Pharmaceutical Review reported that stimulating the production of bnAbs has been pursued as a holy grail in HIV for decades. It is hoped that these specialised blood proteins could attach to HIV surface proteins called spikes, which allow the virus to enter human cells, and disable them via a difficult-to-access regions that does not vary much from strain to strain.

Dr William Schief, a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI’s Neutralizing Antibody Center, whose laboratory developed the vaccine said;

“We and others postulated many years ago that in order to induce bnAbs, you must start the process by triggering the right B cells – cells that have special properties giving them potential to develop into bnAb-secreting cells.

“In this trial, the targeted cells were only about one in a million of all naïve B cells. To get the right antibody response, we first need to prime the right B cells. The data from this trial affirms the ability of the vaccine immunogen to do this.

“This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens as well. With our many collaborators on the study team, we showed that vaccines can be designed to stimulate rare immune cells with specific properties and this targeted stimulation can be very efficient in humans. We believe this approach will be key to making an HIV vaccine and possibly important for making vaccines against other pathogens.”

One of the lead investigators on the trial, Dr Julie McElrath, senior vice president and director of Fred Hutch’s Vaccine and Infectious Disease Division said the trial was “a landmark study in the HIV vaccine field,” adding that they had demonstrated “success in the first step of a pathway to induce broad neutralising antibodies against HIV-1.”

In the Phase I IAVI G001trial, 48 healthy adult volunteers were enrolled to receive either a placebo or two doses of the vaccine compound, eOD-GT8 60mer, along with an adjuvant developed by the GlaxoSmithKline.

The company’s said this study sets the stage for additional clinical trials that will seek to refine and extend the approach, with the long-term goal of creating a safe and effective HIV vaccine. As a next step, the collaborators are partnering with the biotechnology company Moderna to develop and test an mRNA-based vaccine that harnesses the approach to produce the same beneficial immune cells. According to the team, using mRNA technology could significantly accelerate the pace of HIV vaccine development, as it did with vaccines for COVID-19.

Dr Dennis Burton, professor and chair of the Department of Immunology and Microbiology at Scripps Research, scientific director of the IAVI Neutralizing Antibody Center and director of the NIH Consortium for HIV/AIDS Vaccine Development added;

“This is a tremendous achievement for vaccine science as a whole.

“This clinical trial has shown that we can drive immune responses in predictable ways to make new and better vaccines, and not just for HIV. We believe this type of vaccine engineering can be applied more broadly, bringing about a new day in vaccinology.”

It is also believed that same approach could be applied to vaccines for other challenging pathogens such as influenza, dengue, Zika, hepatitis C and malaria.

Facebook Comments
Advertisement

Facebook Comments
Continue Reading

News

Female Police Officer Who Fatally Shot Daunte Wright Identified As Kim Potter

Published

on

Authorities have identified the female officer who fatally shot Daunte Wright during a weekend traffic stop near Minneapolis, sparking protests and unrest.

Kim Potter has been with the Brooklyn Center Police Department for 26 years, the Minnesota Department of Public Safety Bureau of Criminal Apprehension (BCA) said in an emailed statement.

Female Police officer who fatally shot Daunte Wright identified as Kim Potter

The BCA said she’s on standard administrative leave, but would not disclose any further details, citing the active investigation into Wright’s death.

Wright, a 20-year-old Black man was shot and killed during a traffic stop just before 2 p.m. Sunday in Brooklyn Center, after officer Potter said she mistook her taser for a gun and fired at him. He died about 10 miles from where George Floyd, another black man was killed by a Minneapolis police officer last year.

The Hennepin County medical examiner said Wright died of a gunshot wound to the chest, ruling his death as a homicide.

Following the news of his death, hundreds of people gathered to protest, and after a night of unrest, including looting, the National Guard was called in and a curfew was declared.

President Biden has called for any protests against Wright’s shooting to remain “peaceful.”

“There is absolutely no justification, none, for looting, no justification for violence. Peaceful protests, understandable, and the fact is that, you know, we do know that the anger, pain, and trauma that exists in the Black community in that environment is real, it’s serious and it’s consequential. But it will not justify violence and/or looting,” he said.

“And we should listen to Daunte’s mom, who is calling for peace and calm,” he said.

Facebook Comments
Continue Reading

News

President Biden Calls For ‘Peace And Calm’ After A 20-Year-Old Black Man Was Killed By Police In Minnesota

Published

on

President Joe Biden has called for “peace and calm” in the wake of fatal police shooting of Daunte Wright in Minnesota, saying his death does not justify violence or looting.

Wright, a 20-year-old Black man, was fatally shot by female police on Sunday afternoon, pril 11, during a traffic stop in the Minneapolis suburb of Brooklyn Center.

An officer’s body camera footage released on Monday indicated that Wright got out of his car, but then got back in. It’s not clear why, but Brooklyn Center Police Chief Tim Gannon told reporters it appeared from the video that Wright was trying to leave the scene. Gannon also said that the video appeared to show an officer had shouted “Taser!” but fired her handgun accidentally, killing Daunte Wright.

According to Wright’s mother, who had spoken to her son before the shooting, he was pulled over for having an air freshener hanging from his rearview mirror, which is illegal in Minnesota.

Police said Monday that he was stopped for a traffic violation. Brooklyn Center Police Chief Tim Gannon said he believes, based on the body camera video, that the officer who shot Wright mistakenly believed she was firing a Taser and not her gun.

President Biden calls for

Wright was shot about 14 miles north of where George Floyd, another black man was killed last year. Former Minneapolis police Officer Derek Chauvin is on trial charged with second-and third-degree murder. Chauvin knelt on Floyd’s neck for more than nine minutes.

In a tweet, Biden wrote: “Today I’m thinking about Daunte Wright and his family and the pain, anger, and trauma that Black America experiences every day. While we await a full investigation, we know what we need to do to move forward: rebuild trust and ensure accountability so no one is above the law.”

President Biden calls for

Speaking with reporters in the Oval Office about Wright’s death Sunday, President Biden said: “I haven’t called Daunte Wright’s family, but my prayers are with the family. It’s really a tragic thing that happened. The question is was it an accident? Was it intentional? That remains to be determined by a full-blown investigation,” he said, describing the body camera video of the shooting as “fairly graphic.”

Biden called for any protests against Wright’s shooting to remain “peaceful.”

“There is absolutely no justification, none, for looting, no justification for violence. Peaceful protests, understandable, and the fact is that, you know, we do know that the anger, pain, and trauma that exists in the Black community in that environment is real, it’s serious and it’s consequential. But it will not justify violence and/or looting,” he said.

“And we should listen to Daunte’s mom, who is calling for peace and calm,” he said.

Asked whether he would deploy federal resources to help keep the peace, Biden noted that he had already done so because of Chauvin’s trial.

“There are already federal resources,” Biden said. “There will not be a lack of help and support from the federal government if the local authorities believe it’s needed.”

Facebook Comments
Continue Reading

Latest Stories

ad

Trending